Melanoma Antigen-A11 (MAGE-A11) Enhances Transcriptional Activity by Linking Androgen Receptor Dimers

Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation.

Progesterone acting through the progesterone receptor (PR) and its coregulators prepares the human endometrium for receptivity to embryo implantation and maintains pregnancy. The menstrual cycle-dependent expression of melanoma antigen-A11 (MAGE-11) in the mid-secretory human endometrium suggested a novel function in human PR signaling. Here we show that MAGE-11 is an isoform-specific coregulat...

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The presence of paranoid thoughts is not exclusive to clinical disorder; recent data suggest that their prevalence follows an exponential-shaped curve, with many people experiencing a few such thoughts, while a few people experience many such thoughts. Wong et al (pp. 221–229) found that this exponential curve was also evident in their assessment of paranoid thoughts in children, but the freque...

Modulating the Interdomain Interaction Regulates Androgen Receptor Function by Melanoma Antigen Gene Protein MAGE-11

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A whole body physiologically based pharmacokinetic (PBPK) model was applied to investigate absorption, distribution, and physiologic variations on pharmacokinetics of imatinib in human body. Previously published pharmacokinetic data of the drug after intravenous (i.v.) infusion and oral administration were simulated by the PBPK model. Oral dose absorption kinetics were analyzed by adopting a co...

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Previous self-harm is a major predictor of non-fatal repetition and subsequent suicide. Owens et al (pp. 193–199), in a systematic review, estimate the rates of these outcomes following self-harm and find the link between self-harm and suicide to be a strong one. Non-fatal repetition occurred in around 15% of people in the year after an attempt, with up to 2% committing suicide over this time. ...